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WHY AFIRMA


Complex Landscape:

Thyroid nodule diagnosis is challenging



Arriving at an accurate diagnosis and treatment plan requires comprehensive information


ATA guidelines recommend more individualized care, as “…risk stratification is the cornerstone of individualized thyroid cancer management.”2

Afirma enables individualized care and is supported by both ATA and NCCN guidelines

The Afirma Platform:

A unified and simple solution for all of your patients



Gain accurate and clinically actionable results from the first FNA



Afirma has helped over 150,000 patients conclusively rule out surgery or confidently tailor treatment4,6

Low risk

Afirma Genomic Sequencing Classifier:

Conclusively rule out surgery1



Clinically validated through a study published in JAMA Surgery with a blinded, multicenter, prospectively collected cohort1




The only thyroid nodule molecular diagnostic test with reproducible results in independent, real-world studies published in peer-reviewed journals7-12

example

Dependable Hürthle cell performance proven through real-world experience

Hürthle cells are dominant in >20% of indeterminate nodules and have been challenging to classify as high or low risk7,8,11

*Confirmed through histopathologic data from surgically resected nodules
NIFTP = noninvasive follicular thyroid neoplasm with papillary-like nuclear features
high risk

Afirma Xpression Atlas:

Confidently tailor treatment5


Informs selection of surgical and therapeutic decisions5
Clinically validated5 and informed by:
  • The Cancer Genome Atlas (TCGA)14
  • Extensive published literature6
  • Veracyte R&D discovery using nearly 40,000 samples6

The largest thyroid gene and fusion panel available6

Including >100 novel, Veracyte R&D-discovered fusions (of ALK, BRAF, NTRK, RET) that all have importance in patient management6,15

Includes the most clinically relevant and emerging variants and fusions associated with thyroid carcinoma, such as:





Detects variants and fusions that may inform targeted therapy, such as:




Afirma XA is reported for Afirma GSC suspicious and Bethesda V and VI nodules
Afirma Patient Report:

Relevant and actionable results



Provides variant/fusion-specific risk of malignancy (ROM) using clinically relevant evidence
The Afirma XA result may further refine the Afirma GSC suspicious result of ~50% ROM5,6,16


Predicts tumor behavior and informs surgical approach by expression signature14,17



example

Offers additional insight for treatment decisions with:

Afirma GSC and Xpression Atlas:

Count on a simplified experience for your patients and your practice



Veracyte is committed to providing patient access, regardless of financial situation


    • Covered by Medicare with no copayment­6
    • Covered in-network by most commercial payers (over 275 million covered lives)6
    • The Veracyte Access Program supports both uninsured and commercially insured patients with financial need6


Get answers quickly, reduce worry and wait6

    • All-inclusive collection kit
    • Afirma GSC and XA on the same test requisition form


Easily manage patient reports with the Veracyte portal and mobile app

    • Access the Veracyte portal at: portal.veracyte.com
    • Download the Veracyte app from your mobile app store
iOS App Google App

References: 1. Patel KN, et al. JAMA Surg. 2018. 2. Haugen BR, et al. Thyroid 2016. 3. Bongiovanni M, et al. Acta Cytol. 2012. 4. Ali SZ, et al. Cancer Cytopathol. 2019. 5. Angell TE, et al. Front. Endocrinol. 2019. 6. Data on File. 7. Angell TE, et al. Thyroid 2019. 8. San Martin VT, et al. JCEM 2019. 9. Andrioli M, et al. Endocr. Pathol. 2020. 10. Wei S, et al. Cancer Cytopathol. 2019. 11. Harrell RM, et al. Endocr. Pract. 2018. 12. Endo M, et al. Thyroid 2019. 13. Hao Y, et al. BMC Syst. Biol. 2019. 14. TCGA Research Network. Cell 2014. 15. Wirth LJ, et al. ENDO 2020. 16. Goldner WS, et al. Thyroid 2019. 17. Yoo SK, et al. PLOS Genet. 2016.

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